Antibacterial and antimalarial (2,4)-di:amino-pyrimidine derivs. - prepd. e.g. by reacting (2,4)-di:amino-(5)-hydroxy-pyrimidine and aryl(oxy)-alkyl halide cpds.

Pyrimidinederivaten, werkwijzen ter bereiding van deze verbindingen alsmede farmaceutische preparaten die zodanige verbindingen bevatten.

  • Inventors:
  • Assignees: Beecham Group Ltd
  • Publication Date: July 31, 1979
  • Publication Number: NL-7801001-A

Abstract

New 2,4-diaminopyridimidine derivs. have formula (I) In the formula, R is H, CH3 or C2H5; X is 1-10C alkylene; Y is O, S or a direct bond; and Ar is aryl. (I) can be used for the treatment of malaria and/or bacterial infections. Absorption after oral is good, and (I) are active against malaria infections which are resistant to other antimalarials. Specific cpds. (I) include 2,4-diamino-6-methyl-5-(4-chloro-2-cyclohexylphenoxypropoxy)-pyri- midine. In an example, this is prepd. from 2,4-diamino-6-methyl-5-hydroxypyrimidine dihydrochloride and 4-chloro-2-cyclohexylphenoxypropyl bromide.

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